3 boyutlu ( 3D ) biyo yazıcı, biyo uyumlu malzemelerden, hücrelerden ve hücre kültürü ortamı gibi destekleyici bileşenlerden fonksiyonel minyatür doku yapıları üretmek için 3D baskı teknolojisini kullanır…
The concept of developing a bioink that can be used for all cell types and all printing techniques is at best unrealistic and at worst impossible. What is much more achievable and also more desirable is a modifiable, modular system. A base material in which mechanical properties can be easily adapted for the chosen additive method and then formulated for each specific cell type or multiple cell types involved in the end application.
3-dimensional (3D) bioprinting utilises 3D printing technology to produce functional miniaturised tissue constructs from biocompatible materials, cells and supporting components such as cell culture media, and involves the layer-by-layer, accurate deposition of these materials into precise geometries with the goal being the creation of anatomically correct biological structures.
The term ‘bioink’, encompasses materials that mimic an extracellular matrix to support the adhesion, proliferation, and differentiation of living cells in a 3D environment. Bioinks distinguish themselves from traditional biomaterials such as hydrogels, polymer networks, and foam scaffolds due to their ability to be deposited by a 3D printer into a pre-defined structure. There is increasing demand for alternative fabrication approaches to develop tissues and organs as conventional techniques are not capable of fabricating constructs with required structural, mechanical, and biological complexity. 3D bioprinting offers great potential to fabricate highly complex constructs with precise control of structure, mechanics, and biological matter. This is especially relevant in the field of implantable regenerative medicine clinical products.
